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Onion benefits: the quercetin sits in the outer two layers

Onion's antioxidant quercetin concentrates in the outer layers. Peeling two extra layers out of habit throws much of it away.

Ingredient Health Benefits editorial team

Published Jun 2, 2026Updated Oct 12, 20262 min read

Not individually reviewed by a clinician.Editorial policy

Onion
Contents

What it is

The onion is the bulb of a plant in the onion genus, a relative of garlic, leek and chive, native to Central Asia. Cutting one makes your eyes water because the ruptured cells let sulphur compounds meet an enzyme and convert into a volatile that irritates the eye; chilling the onion or using a sharp knife reduces it. Raw it is sharp and harsh, but heat breaks those sulphur compounds down and caramelises the sugars until it is remarkably sweet — the same ingredient tastes like its own opposite depending on how it is cooked.

Scientific name Allium cepa

Onions are how most people get quercetin. Quercetin is a flavonoid studied for anti-inflammatory and antioxidant activity, and for its effect on blood pressure.

What matters is where it sits. Quercetin concentrates in the outer layers and falls off towards the centre. Red onions contain more than white ones.

Key benefits

  1. Moderate evidence

    Quercetin modestly lowers blood pressure

    A meta-analysis of 7 randomised trials (587 patients) found quercetin supplementation lowered systolic pressure by 3.04 mmHg and diastolic by 2.63 mmHg. The effect only appeared at 500 mg a day or more; below that it was not significant. A single onion supplies quercetin in the tens of milligrams — these figures describe a supplement dose, not what you get from eating onions.[1]

  2. Not established

    Blood sugar and lipids are not confirmed

    Several small studies report lower fasting glucose and total cholesterol with onion intake. But a meta-analysis of randomised quercetin trials found that while blood pressure fell, lipid profiles and glucose did not change significantly. On current evidence, only the blood pressure claim holds.[2]

  3. Moderate evidence

    Prebiotic fibre feeds beneficial gut bacteria

    Onions contain inulin and fructo-oligosaccharides, which pass undigested to the colon where bifidobacteria and others feed on them.[3]

  4. Early research

    Sulphur compounds are antimicrobial and anti-inflammatory

    The compounds that sting your eyes belong to the same family as garlic's. Laboratory studies confirm antibacterial activity.[4]

How to eat it well

  • Do not discard the two layers just under the papery skin. A large share of the quercetin is there.
  • Choose red onions to get quercetin and anthocyanins together.
  • Chop and wait ten minutes before cooking, as with garlic, to let more sulphur compounds form.
  • Long caramelising sweetens them while retaining much of the quercetin; boiling in water leaches it out.
  • To reduce eye sting, chill the onion for 30 minutes before cutting; fewer volatiles are released.

How to read the grades

Each benefit carries a label showing how far research on people supports it. Grades differ between items even within the same ingredient.

Nutrition data
A fact verifiable from food composition databases or health authorities. This is a different kind of statement from a clinical effect.
Strong evidence
Consistently confirmed across randomised controlled trials or meta-analyses.
Moderate evidence
Human studies exist, but effect sizes are small or results are mixed.
Early research
Cell or animal work, or small preliminary studies.
Not established
Commonly claimed, but not confirmed in studies on people.

Claims that are not established

What to watch out for

  • Onions are a classic high-FODMAP food and readily cause bloating and gas in irritable bowel syndrome.
  • With acid reflux, raw onion can worsen symptoms.
  • If you take anticoagulants, discuss large intakes with your clinician.
  • They are toxic to dogs and cats — never feed them to pets.

Nutrition

Approximate values per 100 g edible portion.

Calories
40 kcal2%
Fiber
1.7 g6%
Sugars
4.2 g
Protein
1.1 g2%
Vitamin C
7.4 mg8%
Potassium
146 mg3%
Quercetin
20–50 mg

Percentages are of the US FDA Daily Value for adults and children 4 and over. National reference intakes differ by sex and age.

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Sources

The databases and health authorities this article's nutrition figures and health statements draw on.

  1. 1Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsMeta-analysisSerban MC, et al. J Am Heart Assoc 2016PMID 27405810
  2. 2Effect of quercetin supplementation on plasma lipid profiles, blood pressure, and glucose levels: a systematic review and meta-analysisMeta-analysisHuang H, et al. Nutr Rev 2020PMID 31940027
  3. 3Effect of chicory-derived inulin-type fructans on abundance of Bifidobacterium and on bowel function: a systematic review with meta-analysesMeta-analysisLe Bastard Q, et al. Crit Rev Food Sci Nutr 2023PMID 35833477
  4. 4Beneficial Effects of Organosulfur Compounds from Allium cepa on Gut Health: A Systematic ReviewSystematic reviewsGuillamón E, et al. Foods 2021PMID 34441457
  5. 5USDA FoodData CentralFood composition database
  6. 6NIH Office of Dietary SupplementsHealth authority
  7. 7PubMedResearch literature

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